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Urinary NO x (sum of nitrate and nitrite) excretion in response to intraperitoneally administered lipopolysaccharide (LPS) was identical in the control and cystine group (data not shown), demonstrating equal host capacity to produce NO

But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy